Antiarrhythmic Mechanisms of Epidural Blockade After Myocardial Infarction.

ABSTRACT:

Background

Thoracic epidural anesthesia (TEA) has been shown to reduce the burden of ventricular tachycardia in small case series of patients with refractory ventricular tachyarrhythmias and cardiomyopathy. However, its electrophysiological and autonomic effects in diseased hearts remain unclear, and its use after myocardial infarction is limited by concerns for potential right ventricular dysfunction.

Methods

Myocardial infarction was created in Yorkshire pigs (N=22) by left anterior descending coronary artery occlusion. Approximately, six weeks after myocardial infarction, an epidural catheter was placed at the C7-T1 vertebral level for injection of 2% lidocaine. Right and left ventricular hemodynamics were recorded using Millar pressure-conductance catheters, and ventricu

SUBMITTER: Hoang JD 

PROVIDER: S-EPMC11257785 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature