Transfer of celiac disease-associated immunogenic gluten peptides in breast milk: variability in kinetics of secretion.

ABSTRACT:

Background

Exposure to antigens is crucial for child immune system development, aiding disease prevention and promoting infant health. Some common food antigen proteins are found in human breast milk. However, it is unclear whether gluten antigens linked to celiac disease (CD) are transmitted through breast milk, potentially impacting the development of the infant's immune system.

Objective

This study aimed to analyze the passage of gluten immunogenic peptides (GIP) into human breast milk. We evaluated the dynamics of GIP secretion after lactating mothers adopted a controlled gluten-rich diet.

Methods

We prospectively enrolled 96 non-CD and 23 CD lactating mothers, assessing total proteins and casein in breast milk, and GIP levels in breast milk and urine. Subsequentl

SUBMITTER: Ruiz-Carnicer A 

PROVIDER: S-EPMC11257844 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature