Deep learning-enabled classification of kidney allograft rejection on whole slide histopathologic images.

ABSTRACT:

Background

Diagnosis of kidney transplant rejection currently relies on manual histopathological assessment, which is subjective and susceptible to inter-observer variability, leading to limited reproducibility. We aim to develop a deep learning system for automated assessment of whole-slide images (WSIs) from kidney allograft biopsies to enable detection and subtyping of rejection and to predict the prognosis of rejection.

Method

We collected H&E-stained WSIs of kidney allograft biopsies at 400x magnification from January 2015 to September 2023 at two hospitals. These biopsy specimens were classified as T cell-mediated rejection, antibody-mediated rejection, and other lesions based on the consensus reached by two experienced transplant pathologists. To achieve feature extra

SUBMITTER: Ye Y 

PROVIDER: S-EPMC11257957 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature