Cell type mapping of inflammatory muscle diseases highlights selective myofiber vulnerability in inclusion body myositis.

ABSTRACT: Inclusion body myositis (IBM) is the most prevalent inflammatory muscle disease in older adults with no effective therapy available. In contrast to other inflammatory myopathies such as subacute, immune-mediated necrotizing myopathy (IMNM), IBM follows a chronic disease course with both inflammatory and degenerative features of pathology. Moreover, causal factors and molecular drivers of IBM progression are largely unknown. Therefore, we paired single-nucleus RNA sequencing with spatial transcriptomics from patient muscle biopsies to map cell-type-specific drivers underlying IBM pathogenesis compared with IMNM muscles and noninflammatory skeletal muscle samples. In IBM muscles, we observed a selective loss of type 2 myonuclei paralleled by increased levels of cytotoxic T and conventional t

SUBMITTER: Wischnewski S 

PROVIDER: S-EPMC11257986 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature