Impact of bariatric surgery on oral anticancer drugs: an analysis of real-world data.

ABSTRACT:

Purpose

The number of patients with bariatric surgery who receive oral anticancer drugs is rising. Bariatric surgery may affect the absorption of oral anticancer drugs. Strikingly, no specific drug dosing recommendations are available. We aim to provide practical recommendations on the application of oral anticancer drugs in patients who underwent bariatric surgery.

Methods

Patients with any kind of bariatric surgery were extracted retrospectively in a comprehensive cancer center. In addition, a flowchart was proposed to assess the risk of inadequate exposure to oral anticancer drugs in patients who underwent bariatric surgery. Subsequently, the flowchart was evaluated retrospectively using routine Therapeutic drug monitoring (TDM) samples.

Results

In our analysis, 57

SUBMITTER: Lau C 

PROVIDER: S-EPMC11258081 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature