Testing on bacterial vaginosis in a subfertile population and time to pregnancy: a prospective cohort study.

ABSTRACT:

Purpose

This study aimed to investigate the influence of bacterial vaginosis on time to pregnancy in subfertile couples.

Methods

Couples attending a teaching hospital in the Netherlands having an initial fertility assessment (IFA) between July 2019 and June 2022 were included in this prospective study, with follow-up of pregnancies until June 2023. Vaginal samples at IFA were analyzed on pH, qPCR BV, and 16S rRNA gene microbiome analysis of V1-V2 region. Main outcome measures were time from initial fertility assessment to ongoing pregnancy at 12 weeks and live birth, analyzed by Kaplan-Meier and Cox regression with adjustment for potential confounders.

Results

At IFA, 27% of 163 included participants tested positive for BV. BV status had no influence on time to ongoin

SUBMITTER: van den Tweel M 

PROVIDER: S-EPMC11258098 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature