[⁶⁸Ga]Ga-FAPI versus 2-[¹⁸F]FDG PET/CT in patients with autoimmune thyroiditis: a case control study.

ABSTRACT:

Purpose

Radiolabelled fibroblast activation protein inhibitors (FAPIs) are becoming increasingly important for imaging various tumour diseases. However, it is essential to be aware of potential pitfalls. Here, we investigate FAP expression in the thyroid gland in autoimmune thyroiditis (AIT).

Methods

AIT patients with pathological thyroid uptake on [⁶⁸Ga]Ga-FAPI PET were compared with glucose metabolism on 2-[¹⁸F]FDG PET in terms of SUV_max/SUV_peak/SUV_mean/tissue-to-background ratio (TBR), and with a healthy control group.

Results

Between September 2019 and July 2021, 6 patients presented with a visually increased thyroid uptake and TBR on [⁶⁸Ga]Ga-FAPI PET. In the retrospective clinical work-up, all pat

SUBMITTER: Pabst KM 

PROVIDER: S-EPMC11258103 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature