Universal peptide-based potential vaccine design against canine distemper virus (CDV) using a vaccinomic approach.

ABSTRACT: Canine distemper virus (CDV) affects many domestic and wild animals. Variations among CDV genome linages could lead to vaccination failure. To date, there are several vaccine alternatives, such as a modified live virus and a recombinant vaccine; however, most of these alternatives are based on the ancestral strain Onderstepoort, which has not been circulating for years. Vaccine failures and the need to update vaccines have been widely discussed, and the development of new vaccine candidates is necessary to reduce circulation and mortality. Current vaccination alternatives cannot be used in wildlife animals due to the lack of safety data for most of the species, in addition to the insufficient immune response against circulating strains worldwide in domestic species. Computational tools, in

SUBMITTER: Rendon-Marin S 

PROVIDER: S-EPMC11258135 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature