Combined inhibition of KRAS^G12C and mTORC1 kinase is synergistic in non-small cell lung cancer.

ABSTRACT: Current KRAS^G12C (OFF) inhibitors that target inactive GDP-bound KRAS^G12C cause responses in less than half of patients and these responses are not durable. A class of RAS^G12C (ON) inhibitors that targets active GTP-bound KRAS^G12C blocks ERK signaling more potently than the inactive-state inhibitors. Sensitivity to either class of agents is strongly correlated with inhibition of mTORC1 activity. We have previously shown that PI3K/mTOR and ERK-signaling pathways converge on key cellular processes and that inhibition of both pathways is required for inhibition of these processes and for significant antitumor activity. We find here that the combination of a KRAS^G12C inhibitor with a selective mTORC1 kinase inhibitor causes synergistic inh

SUBMITTER: Kitai H 

PROVIDER: S-EPMC11258147 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature