Metabolomic Analysis of Human Cirrhosis and Hepatocellular Carcinoma: A Pilot Study.

ABSTRACT:

Background

Molecular changes in HCC development are largely unknown. As the liver plays a fundamental role in the body's metabolism, metabolic changes are to be expected.

Aims

We aimed to identify metabolomic changes in HCC in comparison to liver cirrhosis (LC) patients, which could potentially serve as novel biomarkers for HCC diagnosis and prognosis.

Methods

Metabolite expression from 38 HCC from the SORAMIC trial and 32 LC patients were analyzed by mass spectrometry. Metabolites with significant differences between LC and HCC at baseline were analyzed regarding expression over follow-up. In addition, association with overall survival was tested using univariate Cox proportional-hazard analysis.

Results

41 metabolites showed differential expression between LC

SUBMITTER: Weber S 

PROVIDER: S-EPMC11258188 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature