Pyridine-based strategies towards nitrogen isotope exchange and multiple isotope incorporation.

ABSTRACT: Isotopic labeling is at the core of health and life science applications such as nuclear imaging, metabolomics and plays a central role in drug development. The rapid access to isotopically labeled organic molecules is a sine qua non condition to support these societally vital areas of research. Based on a rationally driven approach, this study presents an innovative solution to access labeled pyridines by a nitrogen isotope exchange reaction based on a Zincke activation strategy. The technology conceptualizes an opportunity in the field of isotope labeling. ¹⁵N-labeling of pyridines and other relevant heterocycles such as pyrimidines and isoquinolines showcases on a large set of derivatives, including pharmaceuticals. Finally, we explore a nitrogen-to-carbon exchange strategy i

SUBMITTER: Feng M 

PROVIDER: S-EPMC11258231 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature