Tumor-activated in situ synthesis of single-atom catalysts for O₂-independent photodynamic therapy based on water-splitting.

ABSTRACT: Single-atom catalysts (SACs) have attracted interest in photodynamic therapy (PDT), while they are normally limited by the side effects on normal tissues and the interference from the Tumor Microenvironment (TME). Here we show a TME-activated in situ synthesis of SACs for efficient tumor-specific water-based PDT. Upon reduction by upregulated GSH in TME, C₃N₄-Mn SACs are obtained in TME with Mn atomically coordinated into the cavity of C₃N₄ nanosheets. This in situ synthesis overcomes toxicity from random distribution and catalyst release in healthy tissues. Based on the Ligand-to-Metal charge transfer (LMCT) process, C₃N₄-Mn SACs exhibit enhanced absorption in the red-light region. Thereby, a water-splitting process is indu

SUBMITTER: Yin Y 

PROVIDER: S-EPMC11258260 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature