Ontology highlight
ABSTRACT:
SUBMITTER: Wang M
PROVIDER: S-EPMC11258430 | biostudies-literature | 2024 Jul
REPOSITORIES: biostudies-literature
Wang Ming M Zhang Jie J Qiu Jiangping J Ma Xuan X Xu Chenzhong C Wu Qiuhuan Q Xing Shaojun S Chen Xinchun X Liu Baohua B
Aging cell 20240430 7
Beyond the antimicrobial activity, doxycycline (DOX) exhibits longevity-promoting effect in nematodes, while its effect on mammals is unclear. Here, we applied a mouse model of Hutchinson-Gilford progeria syndrome (HGPS), Zmpste24 knockout (KO) mice, and analyzed the antiaging effect of DOX. We found that the DOX treatment prolongs lifespan and ameliorates progeroid features of Zmpste24 KO mice, including the decline of body and tissue weight, exercise capacity and cortical bone density, and the ...[more]