Cerebrospinal fluid proteomic profile of frailty: Results from the PROLIPHYC cohort.

ABSTRACT: Frailty is a clinical state reflecting a decrease in physiological reserve capacities, known to affect numerous biological pathways and is associated with health issues, including neurodegenerative diseases. However, how global protein expression is affected in the central nervous system in frail subject remains underexplored. In this post hoc cross-sectional biomarker analysis, we included 90 adults (52-85 years) suspected of normal pressure hydrocephalus (NPH) and presenting with markers of neurodegenerative diseases. We investigated the human proteomic profile of cerebrospinal fluid associated with frailty defined by an established cumulated frailty index (FI, average = 0.32), not enriched for neurology clinical features. Using a label-free quantitative proteomic approach, we identified

SUBMITTER: Guillotin S 

PROVIDER: S-EPMC11258431 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature