Age-related cholesterol and colorectal cancer progression: Validating squalene epoxidase for high-risk cases.

ABSTRACT: As people age, the risk and progression of colorectal cancer (CRC), along with cholesterol levels, tend to increase. Nevertheless, epidemiological studies on serum lipids and CRC have produced conflicting results. We previously demonstrated that the reduction of squalene epoxidase (SQLE) due to accumulated cholesterol within cells accelerates CRC progression through the activation of the β-catenin pathway. This study aimed to investigate the mechanism by which age-related cholesterol accumulation within tissue accelerates CRC progression and to assess the clinical significance of SQLE in older individuals with elevated CRC risk. Using machine learning-based digital image analysis with fluorescence-immunohistochemistry, we assessed SQLE, GSK3β^pS9 (GSK3β activity inhibition throug

SUBMITTER: Jun SY 

PROVIDER: S-EPMC11258466 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature