Genetically determined blood pressure, antihypertensive drug classes, and frailty: A Mendelian randomization study.

ABSTRACT: Observational studies have suggested that the use of antihypertensive drugs was associated with the risk of frailty; however, these findings may be biased by confounding and reverse causality. This study aimed to explore the effect of genetically predicted lifelong lowering blood pressure (BP) through different antihypertensive medications on frailty. One-sample Mendelian randomization (MR) and summary data-based MR (SMR) were applied. We utilized two kinds of genetic instruments to proxy the antihypertensive medications, including genetic variants within or nearby drugs target genes associated with systolic/diastolic BP, and expression level of the corresponding gene. Among 298,618 UK Biobank participants, one-sample MR analysis observed that genetically proxied BB use (relative risk rati

SUBMITTER: Zhuang Z 

PROVIDER: S-EPMC11258474 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature