Low-Density Lipoprotein Cholesterol, Cardiovascular Disease Risk, and Mortality in China.

ABSTRACT:

Importance

Limited evidence supports the association between low-density lipoprotein cholesterol (LDL-C) and mortality across different atherosclerotic cardiovascular disease (ASCVD) risk stratifications.

Objective

To explore the associations between LDL-C levels and mortality and to identify the optimal ranges of LDL-C with the lowest risk of mortality in populations with diverse ASCVD risk profiles.

Design, setting, and participants

The ChinaHEART project is a prospective cohort study that recruited residents aged 35 to 75 years from 31 provinces in mainland China between November 2014 and December 2022. Participants were categorized into low-risk, primary prevention, and secondary prevention cohorts on the basis of their medical history and ASCVD risk. Data analysi

SUBMITTER: Chen L 

PROVIDER: S-EPMC11258592 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature