Liver metastases across cancer types sharing tumor environment immunotolerance can impede immune response therapy and immune monitoring.

ABSTRACT:

Background

Hepatic immune tolerance might contribute to the development of therapeutic resistance to immunotherapy. However, addressing this issue is challenging since the efficacy of immunotherapy in the context of liver metastasis (LM) remains poorly studied. Here, we aimed to establish an LM common immune feature (LMCIF) score to quantify the characteristics of LM immunotolerance across cancer types for assisting clinical disease management.

Methods

Large-scale clinical data were collected to identify the prognosis of LM. Multi-omics datasets of metastatic cancers with LM special immune-related pathways (LMSIPs) from the Molecular Signatures Database (MSigDB)were used to obtain an LMCIF cluster. Based on differential expression genes (DEGs), a novel LMCIF score for the LM

SUBMITTER: Gao Y 

PROVIDER: S-EPMC11258657 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature