Lipidomic analysis identifies long-chain acylcarnitine as a target for ischemic stroke.

ABSTRACT:

Introduction

Lipid metabolism dysfunction is widely involved in the pathological process of acute ischemic stroke (AIS). The coordination of lipid metabolism between neurons and astrocytes is of great significance. However, the full scope of lipid dynamic changes and the function of key lipids during AIS remain unknown. Hence, identifying lipid alterations and characterizing their key roles in AIS is of great importance.

Methods

Untargeted and targeted lipidomic analyses were applied to profile lipid changes in the ischemic penumbra and peripheral blood of transient middle cerebral artery occlusion (tMCAO) mice as well as the peripheral blood of AIS patients. Infarct volume and neurological deficits were assessed after tMCAO. The cell viability and dendritic complexity of pr

SUBMITTER: Huang XX 

PROVIDER: S-EPMC11258661 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature