Evolocumab prevents atrial fibrillation in rheumatoid arthritis rats through restraint of PCSK9 induced atrial remodeling.

ABSTRACT:

Introduction

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is implicated in the pathogenesis and progression of autoimmune disease. Patients with rheumatoid arthritis (RA) are at high risk of developing atrial fibrillation (AF), while whether PCSK9 is involved in the onset of AF among RA patients remains unclear.

Objectives

To explore the role of PCSK9 in the occurrence of AF in RA patients and decipher the underlying mechanism.

Methods

We established a rat model of collagen-induced arthritis (CIA) by immunization with type II collagen in Freund's incomplete adjuvant. Atrial electrophysiological test was used to evaluate AF susceptibility. We performed a clinical study to examine the correlation between PCSK9 level and AF, which recruited healthy control, RA p

SUBMITTER: Han X 

PROVIDER: S-EPMC11258665 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature