Deciphering mechanisms of cardiomyocytes and non-cardiomyocyte transformation in myocardial remodeling of permanent atrial fibrillation.

ABSTRACT:

Introduction

Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia, and it significantly increases the risk of cardiovascular complications and morbidity, even with appropriate treatment. Tissue remodeling has been a significant topic, while its systematic transcriptional signature remains unclear in AF.

Objectives

Our study aims to systematically investigate the molecular characteristics of AF at the cellular-level.

Methods

We conducted single-nuclei RNA-sequencig (snRNA-seq) analysis using nuclei isolated from the left atrial appendage (LAA) of AF patients and sinus rhythm. Pathological staining was performed to validate the key findings of snRNA-seq.

Results

A total of 30 cell subtypes were identified among 80, 592 nuclei. Within the LAA of AF, w

SUBMITTER: Sheng Y 

PROVIDER: S-EPMC11258668 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature