Identification of necroptosis-related genes in ankylosing spondylitis by bioinformatics and experimental validation.

ABSTRACT: The pathogenesis of ankylosing spondylitis (AS) remains unclear, and while recent studies have implicated necroptosis in various autoimmune diseases, an investigation of its relationship with AS has not been reported. In this study, we utilized the Gene Expression Omnibus database to compare gene expressions between AS patients and healthy controls, identifying 18 differentially expressed necroptosis-related genes (DENRGs), with 8 upregulated and 10 downregulated. Through the application of three machine learning algorithms-least absolute shrinkage and selection operation, support vector machine-recursive feature elimination and random forest-two hub genes, FASLG and TARDBP, were pinpointed. These genes demonstrated high specificity and sensitivity for AS diagnosis, as evidenced by receive

SUBMITTER: Wen P 

PROVIDER: S-EPMC11258886 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature