Homogeneous Organic Reductant Based on 4,4'-^tBu₂-2,2'-Bipyridine for Cross-Electrophile Coupling.

ABSTRACT: The synthesis of a new homogeneous reductant based on 4,4'-^tBu₂-2,2'-bipyridine, ^tBu-OED₄, is reported. ^tBu-OED₄ was prepared on a multigram scale in two steps from inexpensive and commercially available starting materials, with no chromatography required for purification. ^tBu-OED₄ has a reduction potential of -1.33 V (vs Ferrocenium/Ferrocene) and is soluble in a range of common organic solvents. We demonstrate that ^tBu-OED₄ can facilitate Ni/Co dual-catalyzed C(sp²)-C(sp³) cross-electrophile coupling reactions and is highly functional group tolerant. ^tBu-OED₄ is expected to be a valuable addition to the set of homogeneous reductants ava

SUBMITTER: Charboneau DJ 

PROVIDER: S-EPMC11258959 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature