Topological regularization of networks in temporal lobe epilepsy: a structural MRI study.

ABSTRACT:

Objective

Patients with temporal lobe epilepsy (TLE) often exhibit neurocognitive disorders; however, we still know very little about the pathogenesis of cognitive impairment in patients with TLE. Therefore, our aim is to detect changes in the structural connectivity networks (SCN) of patients with TLE.

Methods

Thirty-five patients with TLE were compared with 47 normal controls (NC) matched according to age, gender, handedness, and education level. All subjects underwent thin-slice T1WI scanning of the brain using a 3.0 T MRI. Then, a large-scale structural covariance network was constructed based on the gray matter volume extracted from the structural MRI. Graph theory was then used to determine the topological changes in the structural covariance network of TLE patients.

SUBMITTER: Chen Y 

PROVIDER: S-EPMC11259028 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature