Myelin dystrophy impairs signal transmission and working memory in a multiscale model of the aging prefrontal cortex.

ABSTRACT: Normal aging leads to myelin alterations in the rhesus monkey dorsolateral prefrontal cortex (dlPFC), which are positively correlated with degree of cognitive impairment. It is hypothesized that remyelination with shorter and thinner myelin sheaths partially compensates for myelin degradation, but computational modeling has not yet explored these two phenomena together systematically. Here, we used a two-pronged modeling approach to determine how age-related myelin changes affect a core cognitive function: spatial working memory. First, we built a multicompartment pyramidal neuron model fit to monkey dlPFC empirical data, with an axon including myelinated segments having paranodes, juxtaparanodes, internodes, and tight junctions. This model was used to quantify conduction velocity (CV) cha

SUBMITTER: Ibanez S 

PROVIDER: S-EPMC11259433 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature