Gut microbiota, skin microbiota, and alopecia areata: A Mendelian randomization study.

ABSTRACT:

Background

Observational studies have shown an association between skin microbiota and alopecia areata (AA), but the causal connection remains ambiguous.

Methods

We obtained data on skin microbiota and AA from summary statistics of Genome-Wide Association Studies and applied statistical methods from Mendelian randomization (MR) to assess causal relationships. Additionally, we investigated whether the skin microbiota acts as a mediator in the pathway from gut microbiota to AA.

Results

In the MR analysis of KORA FF4 and AA, the inverse-variance weighting method indicated that Corynebacterium (odds ratio [OR] = 0.82, 95% confidence interval [CI]: 0.70-0.96, p = 0.02) and asv037 (OR = 0.87, 95% CI: 0.76-0.99, p = 0.05) exerted protective effects, while Betaproteobacteria

SUBMITTER: Li Z 

PROVIDER: S-EPMC11259542 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature