Characterizing normal perinatal development of the human brain structural connectivity.

ABSTRACT: Early brain development is characterized by the formation of a highly organized structural connectome, which underlies brain's cognitive abilities and influences its response to diseases and environmental factors. Hence, quantitative assessment of structural connectivity in the perinatal stage is useful for studying normal and abnormal neurodevelopment. However, estimation of the connectome from diffusion MRI data involves complex computations. For the perinatal period, these computations are further challenged by the rapid brain development, inherently low signal quality, imaging difficulties, and high inter-subject variability. These factors make it difficult to chart the normal development of the structural connectome. As a result, there is a lack of reliable normative baselines of stru

SUBMITTER: Wu Y 

PROVIDER: S-EPMC11259574 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature