Predicting Efficacies of Fractional Doses of Vaccines by Using Neutralizing Antibody Levels: Systematic Review and Meta-Analysis.

ABSTRACT:

Background

With the emergence of SARS-CoV-2 variants that have eluded immunity from vaccines and prior infections, vaccine shortages and vaccine effectiveness pose unprecedented challenges for governments in expanding booster vaccination programs. The fractionation of vaccine doses might be an effective strategy for helping society to face these challenges, as fractional doses may have efficacies comparable with those of the standard doses.

Objective

This study aims to investigate the relationship between vaccine immunogenicity and protection and to project efficacies of fractional doses of vaccines for COVID-19 by using neutralizing antibody levels.

Methods

In this study, we analyzed the relationship between in vitro neutralization levels and the observed efficacies

SUBMITTER: Du Z 

PROVIDER: S-EPMC11259582 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature