Profiles of peripheral B cell subsets in a cohort of primary Sjogren's syndrome patients and their potential clinical significance.

ABSTRACT:

Background/purpose

Primary Sjögren's syndrome is a prototypical autoimmune disease, with B cell dysfunction as a dominant feature. Further insights into distribution of B cell subsets in primary Sjögren's syndrome are urgently required to identify the most appropriate target subpopulation. We aimed to evaluate the profiles of B lymphocyte subpopulations in primary Sjögren's syndrome patients and to investigate their clinical significance.

Materials and methods

Thirty primary Sjögren's syndrome patients and 15 age-and sex-matched healthy controls were recruited. Peripheral B cell subsets were analyzed by flow cytometry.

Results

Compared to healthy controls, circulating CD19⁺ B cells, CD19⁺CD20^- B cells, CD19⁺CD27^-I

SUBMITTER: Xing Y 

PROVIDER: S-EPMC11259624 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature