Comparison of the penile microbiome in infant male circumcision: Mogen clamp versus Shangring.

ABSTRACT:

Background

This study aimed to characterise the infant penile (coronal sulcus) microbiome and the effects of early infant male circumcision (EIMC), following a standard surgical method (Mogen Clamp) and a non-surgical alternative (ShangRing).

Methods

We collected coronal sulcus swabs at baseline and on days 7 and 14 post-circumcision from infants assigned to receive EIMC by Mogen Clamp (n = 15) or ShangRing (n = 15), in a randomised trial in Rakai and Kakuuto, Uganda. We used 16S rRNA gene-based sequencing and broad-coverage qPCR to characterise the infant penile microbiome and assess the effects of EIMC in both study arms.

Findings

Prior to EIMC, the infant penile microbiome had a mixture of facultative and strict anaerobes. In both study arms, EIMC caused penile mic

SUBMITTER: Salazar JE 

PROVIDER: S-EPMC11259695 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature