Exploratory multi-omics analysis reveals host-microbe interactions associated with disease severity in psoriatic skin.

ABSTRACT:

Background

Psoriasis (Pso) is a chronic inflammatory skin disease that poses both physical and psychological challenges. Dysbiosis of the skin microbiome has been implicated in Pso, yet a comprehensive multi-omics analysis of host-microbe interactions is still lacking. To bridge this gap, we conducted an exploratory study by adopting the integrated approach that combines whole metagenomic shotgun sequencing with skin transcriptomics.

Methods

This was a cross-sectional study, adult patients with plaque-type Psoriasis (Pso) and healthy volunteers were included. Skin microbiota samples and biopsies were collected from both lesional and non-lesional skin areas on the lower back. Weighted Gene Correlation Network Analysis (WGCNA) was employed for co-expression network analysis, a

SUBMITTER: Yang Y 

PROVIDER: S-EPMC11259698 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature