Comprehensive bioinformatics analysis and cell line experiments revealed the important role of CDCA3 in sarcoma.

ABSTRACT:

Background

Sarcoma mainly originate from bone and soft tissue and are highly aggressive malignant tumors. Cell division cycle-related protein 3 (CDCA3) is a protein involved in the regulation of the cell cycle, which is highly expressed in a variety of malignant tumors. However, its role in sarcoma remains unclear. This study aims to investigate the function and potential mechanism of CDCA3 in sarcoma and to elucidate its importance in sarcoma.

Methods

We first studied the expression and prognosis of CDCA family members in sarcoma by Oncomine and the Gene Expression Profiling Interactive Analysis (GEPIA). The role of CDCA3 protein in sarcoma was further analyzed by the Cancer Genome Atlas Program (TCGA), the Cancer Cell Lineage Encyclopedia (CCLE), and Linke-dOmics. In addit

SUBMITTER: Li Y 

PROVIDER: S-EPMC11259814 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature