Integrated analysis of histone modification features in clear cell renal cancer for risk stratification and therapeutic prediction.

ABSTRACT: Clear cell renal cell carcinoma (ccRCC) is a common urological malignancy that is involved in tumor genesis and development. However, few studies have focused on the predictive role of the global histone modification status in ccRCC. A total of 621 patients with complete transcript information and corresponding clinical profiles were obtained from TCGA-KIRC, GSE22541, and EMTAB3267 cohorts. A total of 122 histone modification relevant pathways were derived from MSigDB, and their activation status was quantified using GSVA. Differentially expressed genes (DEGs) were identified and filtrated using univariate Cox regression analysis. The signature was built relied on the least absolute shrinkage and selection operator (LASSO) regression analysis, and evaluated from survival difference, chemot

SUBMITTER: Ma W 

PROVIDER: S-EPMC11259817 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature