Sex-specific associations between prolonged serum uric acid levels and risk of major adverse cardiovascular events.

ABSTRACT:

Background

While hyperuricemia has been correlated with cardiovascular (CV) diseases, further evidence is required to evaluate the implications of stable serum uric acid (sUA) levels, especially concerning low sUA. This study aimed to investigate prolonged stable sUA levels and CV events/mortality.

Methods

We conducted a retrospective cohort study at a medical center using electronic medical records linked with the national claims database. Patients with at least two sUA measurements, with intervals ranging from 6 months to 4 years, were included. The mean of the first two eligible sUA measurements were analyzed, stratified by sex. Outcomes of interest comprised major adverse cardiovascular events (MACE), heart failure hospitalization, CV and all-cause mortality.

Results<

SUBMITTER: Chien HT 

PROVIDER: S-EPMC11259864 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature