Disability and Recurrent Stroke Among Participants in Stroke Prevention Trials.

ABSTRACT:

Importance

Stroke secondary prevention trials have disproportionately enrolled participants with mild or no disability. The impact of this bias remains unclear.

Objective

To investigate the association between poststroke disability and the rate of recurrent stroke during long-term follow up.

Design, setting, and participants

This cohort study is a post hoc analysis of the Prevention Regimen For Effectively Avoiding Second Strokes (PRoFESS) and Insulin Resistance Intervention After Stroke (IRIS) secondary prevention clinical trial datasets. PRoFESS enrolled patients from 2003 to 2008, and IRIS enrolled patients from 2005 to 2015. Data were analyzed from September 23, 2023, to May 16, 2024.

Exposure

The exposure was poststroke functional status at study baseline,

SUBMITTER: de Havenon A 

PROVIDER: S-EPMC11259901 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature