HLA reduction of human T cells facilitates generation of immunologically multicompatible cellular products.

ABSTRACT:

Abstract

Adoptive cellular therapies have shown enormous potential but are complicated by personalization. Because of HLA mismatch, rejection of transferred T cells frequently occurs, compromising the T-cell graft's functionality. This obstacle has led to the development of HLA knock-out (KO) T cells as universal donor cells. Whether such editing directly affects T-cell functionality remains poorly understood. In addition, HLA KO T cells are susceptible to missing self-recognition through natural killer (NK) cells and lack of canonical HLA class I expression may represent a safety hazard. Engineering of noncanonical HLA molecules could counteract NK-cell recognition, but further complicates the generation of cell products. Here, we show that HLA KO does not alter T-cell functionali

SUBMITTER: Winterhalter PM 

PROVIDER: S-EPMC11259936 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature