Association between obesity and statin use on mortality and hospital encounters in atrial fibrillation.

ABSTRACT:

Background

Obesity increases risk of atrial fibrillation (AF) at least in part due to pro-inflammatory effects, but has been paradoxically associated with improved mortality. Although statins have pleiotropic anti-inflammatory properties, their interaction with obesity and clinical outcomes in AF is unknown. We explored the relationship between BMI, statin use, and all-cause mortality and AF/congestive heart failure (CHF)-related encounters, hypothesizing that statin exposure may be differentially associated with improved outcomes in overweight/obesity.

Methods

This was a single center retrospective cohort study of adults with AF diagnosed between 2011-2018. Patients were grouped by body mass index (BMI) and statin use at time of AF diagnosis. Outcomes included all-cause mor

SUBMITTER: Hill MC 

PROVIDER: S-EPMC11260021 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature