Identifying and distinguishing cognitive profiles among virally suppressed people with HIV.

ABSTRACT:

Objective

Cognitive deficits are common among people with HIV (PWH), even when virally suppressed. We identified cognitive profiles among virally suppressed PWH and determined how sociodemographic, clinical/behavioral, and HIV disease characteristics distinguish profile membership.

Method

Participants included 704 virally suppressed PWH (M_age = 43.9 [SD = 10.2], 88% male, 58.9% non-Hispanic White) from the HIV Neurobehavioral Research Program. Demographically adjusted T scores were derived from a neuropsychological evaluation comprised of 13 tests. We implemented a pipeline involving dimension reduction and clustering to identify profiles of cognitive performance. Random forest models on a 70/30 training/testing set with internal cross-validation wer

SUBMITTER: Sundermann EE 

PROVIDER: S-EPMC11260085 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature