Antigen-specific age-related memory CD8 T cells induce and track Alzheimer's-like neurodegeneration.

ABSTRACT: Cerebral (Aβ) plaque and (pTau) tangle deposition are hallmarks of Alzheimer's disease (AD), yet are insufficient to confer complete AD-like neurodegeneration experimentally. Factors acting upstream of Aβ/pTau in AD remain unknown, but their identification could enable earlier diagnosis and more effective treatments. T cell abnormalities are emerging AD hallmarks, and CD8 T cells were recently found to mediate neurodegeneration downstream of tangle deposition in hereditary neurodegeneration models. The precise impact of T cells downstream of Aβ/pTau, however, appears to vary depending on the animal model. Our prior work suggested that antigen-specific memory CD8 T ("^hiT") cells act upstream of Aβ/pTau after brain injury. Here, we examine whether ^hiT cells influence sp

SUBMITTER: Panwar A 

PROVIDER: S-EPMC11260139 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature