Histone deacetylase Hos2 regulates protein expression noise by potentially modulating the protein translation machinery.

ABSTRACT: Non-genetic variations derived from expression noise at transcript or protein levels can result in cell-to-cell heterogeneity within an isogenic population. Although cells have developed strategies to reduce noise in some cellular functions, this heterogeneity can also facilitate varying levels of regulation and provide evolutionary benefits in specific environments. Despite several general characteristics of cellular noise having been revealed, the detailed molecular pathways underlying noise regulation remain elusive. Here, we established a dual-fluorescent reporter system in Saccharomyces cerevisiae and performed experimental evolution to search for mutations that increase expression noise. By analyzing evolved cells using bulk segregant analysis coupled with whole-genome sequencing, we

SUBMITTER: Lin WH 

PROVIDER: S-EPMC11260488 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature