Alveolar hypoxia induces organ-specific inflammasome-related inflammation in male mouse lungs.

ABSTRACT: Inflammation through activation of caspase-1, seems to play a role in pulmonary hypertension induced by alveolar hypoxia. Whether alveolar hypoxia induces caspase-1-mediated inflammation and influx of leukocytes in other organs than the lungs, is not known. Our aim was to explore sites of caspase-1-related inflammation in alveolar hypoxia. Wild type (WT) mice were exposed to environmental hypoxia or room-air, and organs were analyzed. Right heart catheterization was performed after 14 days of alveolar hypoxia in WT mice and mice transplanted with WT or caspase-1^-/- bone marrow. Hypoxia induced leukocyte accumulation and increased caspase-1 protein in the lungs, not in other organs. WT mice transplanted with WT or caspase-1^-/- bone marrow showed no difference in pulmon

SUBMITTER: Udjus C 

PROVIDER: S-EPMC11260499 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature