Urinary Plasminogen as a Marker of Disease Progression in Human Glomerular Disease.

ABSTRACT:

Rationale & objective

Glomerular disorders have a highly variable clinical course, and biomarkers that reflect the molecular mechanisms underlying their progression are needed. Based on our previous work identifying plasminogen as a direct cause of podocyte injury, we designed this study to test the association between urine plasmin(ogen) (ie, plasmin and its precursor plasminogen) and end-stage kidney disease (ESKD).

Study design

Multicenter cohort study.

Setting & participants

1,010 patients enrolled in the CureGN Cohort with biopsy-proven glomerular disease (focal segmental glomerulosclerosis, membranous nephropathy, and immunoglobulin A nephropathy).

Predictors

The main predictor was urine plasmin(ogen) at baseline. Levels were measured by an electrochemilu

SUBMITTER: de Cos M 

PROVIDER: S-EPMC11260534 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature