Amphiregulin-producing T_H2 cells facilitate esophageal fibrosis of eosinophilic esophagitis.

ABSTRACT:

Background

Massive eosinophil infiltration into the esophagus is associated with subepithelial fibrosis and esophageal stricture in patients with eosinophilic esophagitis (EoE). However, the pathogenesis of esophageal fibrosis remains unclear.

Objective

We sought to elucidate the cellular and molecular mechanisms underlying the induction of esophageal fibrosis.

Methods

We established a murine model of EoE accompanied by fibrotic responses following long-term intranasal administration of house dust mite antigen. Using this murine model, we investigated the characteristics of immune cells infiltrating the fibrotic region of the inflamed esophagus using flow cytometry and histological analyses. We also analyzed the local inflammatory sites in the esophagus of patients wi

SUBMITTER: Kaneko T 

PROVIDER: S-EPMC11260569 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature