Association between inflammatory bowel disease and the risk of parenteral malignancies: A two-sample Mendelian randomization study.

ABSTRACT:

Aim

Using Mendelian Randomization (MR) analysis to investigate the potential causal association between Inflammatory Bowel Disease (IBD) and the occurrence of parenteral malignancies, in order to provide some reference for the parenteral malignancy prevention in patients with IBD.

Methods

This was a two-sample MR study based on independent genetic variants strongly linked to IBD selected from the Genome-Wide Association Study (GWAS) meta-analysis carried out by the International Inflammatory Bowel Disease Genetics Consortium (IIBDGC). Parenteral malignancy cases and controls were obtained from the FinnGen consortium and the UK Biobank (UKB) release data. Inverse Variance Weighted (IVW), weighted median, MR-Egger, and strength test (F) were utilized to explore the causal asso

SUBMITTER: Su P 

PROVIDER: S-EPMC11260596 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature