Prognostic value of HPV circulating tumor DNA detection and quantification in locally advanced cervical cancer.

ABSTRACT:

Background

Cervical cancers are mainly caused by an oncogenic HPV. For locally advanced stages, the standard treatment is radio-chemotherapy (RTCT) followed by brachytherapy. Nevertheless, the prognosis remains highly heterogeneous between patients.

Objective

We investigated the prognostic value of HPV circulating tumor DNA (ctDNA) in locally advanced cervical cancers alongside that of Squamous Cell Carcinoma Antigen (SCC-A).

Methods

This single-center retrospective study included patients treated in curative intent for an IB3 to IVA squamous cell cervical cancer. Quantification of HPV ctDNA in serum collected at diagnosis was performed using a multiplex digital PCR assay for the simultaneous detection of 8 HPV genotypes.

Results

Among the 97 patients included,

SUBMITTER: Beaussire-Trouvay L 

PROVIDER: S-EPMC11260666 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature