The causal relationship between human brain morphometry and knee osteoarthritis: a two-sample Mendelian randomization study.

ABSTRACT:

Background

Knee Osteoarthritis (KOA) is a prevalent and debilitating condition affecting millions worldwide, yet its underlying etiology remains poorly understood. Recent advances in neuroimaging and genetic methodologies offer new avenues to explore the potential neuropsychological contributions to KOA. This study aims to investigate the causal relationships between brain-wide morphometric variations and KOA using a genetic epidemiology approach.

Method

Leveraging data from 36,778 UK Biobank participants for human brain morphometry and 487,411 UK Biobank participants for KOA, this research employed a two-sample Mendelian Randomization (TSMR) approach to explore the causal effects of 83 brain-wide volumes on KOA. The primary method of analysis was the Inverse Variance Weight

SUBMITTER: Liu Y 

PROVIDER: S-EPMC11260717 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature