A three-step, "brute-force" approach toward optimized affine spatial normalization.

ABSTRACT: The first step in spatial normalization of magnetic resonance (MR) images commonly is an affine transformation, which may be vulnerable to image imperfections (such as inhomogeneities or "unusual" heads). Additionally, common software solutions use internal starting estimates to allow for a more efficient computation, which may pose a problem in datasets not conforming to these assumptions (such as those from children). In this technical note, three main questions were addressed: one, does the affine spatial normalization step implemented in SPM12 benefit from an initial inhomogeneity correction. Two, does using a complexity-reduced image version improve robustness when matching "unusual" images. And three, can a blind "brute-force" application of a wide range of parameter combinations imp

SUBMITTER: Wilke M 

PROVIDER: S-EPMC11260722 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature