Codon usage bias in yeasts and its correlation with gene expression, growth temperature, and protein structure.

ABSTRACT: Codon usage bias (CUB) has been described in viruses, prokaryotes, and eukaryotes and has been linked to several cellular and environmental factors, such as the organism's growth temperature, gene expression levels, and regulation of protein synthesis and folding. Most of the studies in this area have been conducted in bacteria and higher eukaryotes, in some cases with different results. In this study, a comparative analysis of CUB in yeasts isolated from cold and template environments was performed in order to evaluate the correlation of CUB with yeast optimal temperature of growth (OTG), gene expression levels, cellular function, and structure of encoded proteins. Among the main findings, highly expressed ORFs tend to have a more similar CUB within and between yeasts, and a direct correl

SUBMITTER: Baeza M 

PROVIDER: S-EPMC11260810 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature