Canthin-6-one analogs block Newcastle disease virus proliferation via suppressing the Akt and ERK pathways.

ABSTRACT: Newcastle disease virus, a member of the Paramyxoviridae family, causes significant economic losses in poultry worldwide. To identify novel antiviral agents against NDV, 36 canthin-6-one analogs were evaluated in this study. Our data showed that 8 compounds exhibited excellent inhibitory effects on NDV replication with IC₅₀ values in the range of 5.26 to 11.76 μM. Besides, these analogs inhibited multiple NDV strains with IC₅₀ values within 12 μM and exerted antiviral activity against peste des petits ruminants virus (PPRV) and canine distemper virus (CDV). Among these analogs, 16 presented the strongest anti-NDV activity (IC₅₀ = 5.26 μM) and minimum cytotoxicity (CC₅₀ > 200 μM) in DF-1 cells. Furthermore, 16 displayed antiviral activity in diffe

SUBMITTER: Wang C 

PROVIDER: S-EPMC11261124 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature