Dataset Information

Dynamic analysis of acute deterioration in chronic liver disease patients using modified quick sequential organ failure assessment.

ABSTRACT:

Background/aims

Quick sequential organ failure assessment (qSOFA) is believed to identify patients at risk of poor outcomes in those with suspected infection. We aimed to evaluate the ability of modified qSOFA (m-qSOFA) to identify high-risk patients among those with acutely deteriorated chronic liver disease (CLD), especially those with acute-onchronic liver failure (ACLF).

Methods

We used data from both the Korean Acute-on-Chronic Liver Failure (KACLiF) and the Asian Pacific Association for the Study of the Liver ACLF Research Consortium (AARC) cohorts. qSOFA was modified by replacing the Glasgow Coma Scale with hepatic encephalopathy, and an m-qSOFA ≥2 was considered high.

Results

Patients with high m-qSOFA had a significantly lower 1-month transplant-free survival (TFS) in both cohorts and higher organ failure development in KACLiF than those with low m-qSOFA (Ps<0.05). Subgroup analysis by ACLF showed that patients with high m-qSOFA had lower TFS than those with low m-qSOFA. m-qSOFA was an independent prognostic factor (hazard ratios, HR=2.604, 95% confidence interval, CI 1.353-5.013, P=0.004 in KACLiF and HR=1.904, 95% CI 1.484- 2.442, P<0.001 in AARC). The patients with low m-qSOFA at baseline but high m-qSOFA on day 7 had a significantly lower 1-month TFS than those with high m-qSOFA at baseline but low m-qSOFA on day 7 (52.6% vs. 89.4%, P<0.001 in KACLiF and 26.9% vs. 61.5%, P<0.001 in AARC).

Conclusion

Baseline and dynamic changes in m-qSOFA may identify patients with a high risk of developing organ failure and short-term mortality among CLD patients with acute deterioration.

SUBMITTER: Song DS

PROVIDER: S-EPMC11261223 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature

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Publications

Dynamic analysis of acute deterioration in chronic liver disease patients using modified quick sequential organ failure assessment.

Song Do Seon DS Kim Hee Yeon HY Jung Young Kul YK Kim Tae Hyung TH Yim Hyung Joon HJ Yoon Eileen L EL Suk Ki Tae KT Yoo Jeong-Ju JJ Kim Sang Gyune SG Kim Moon Young MY Chang Young Y Jeong Soung Won SW Jang Jae Young JY Kim Sung-Eun SE Kim Jung-Hee JH Park Jung Gil JG Kim Won W Yang Jin Mo JM Kim Dong Joon DJ Choudhury Ashok Kumar AK Arora Vinod V Sarin Shiv Kumar SK

Clinical and molecular hepatology 20240411 3

<h4>Background/aims</h4>Quick sequential organ failure assessment (qSOFA) is believed to identify patients at risk of poor outcomes in those with suspected infection. We aimed to evaluate the ability of modified qSOFA (m-qSOFA) to identify high-risk patients among those with acutely deteriorated chronic liver disease (CLD), especially those with acute-onchronic liver failure (ACLF).<h4>Methods</h4>We used data from both the Korean Acute-on-Chronic Liver Failure (KACLiF) and the Asian Pacific Ass ...[more]

PMID: 38600873

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Dataset Information

Dynamic analysis of acute deterioration in chronic liver disease patients using modified quick sequential organ failure assessment.

Background/aims

Methods

Results

Conclusion

Publications

Dynamic analysis of acute deterioration in chronic liver disease patients using modified quick sequential organ failure assessment.

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